Camelpox virus is the causative agent of Camelpox, a highly contagious disease of camels. A high passage Camelpox virus strain has previously been reported to contain several genes which more closely resemble Vaccinia, a virus species with no known natural host, encompassing various strains that show high inter-strain genomic variation. In this study, we demonstrate that yet another high passage, live attenuated vaccine, comprising a different strain of Camelpox virus, contains genomic sequences that match a differing strain of Vaccinia virus. These results are discussed in the context of hypotheses put forward to explain the unknown origins of Vaccinia virus, suggesting further studies to elucidate evolutionary trajectories of Orthopoxviruses through passaging.

骆驼痘病毒是骆驼传染性极强的骆驼疾病的病原体。先前已经报道了高传代的骆驼痘病毒株包含多个基因，这些基因更类似于痘苗，这是一种没有已知天然宿主的病毒，涵盖了显示高株间基因组变异的各种菌株。在这项研究中，我们证明了另一种高通量减毒活疫苗，包含不同的骆驼痘病毒株，其基因组序列与不同的痘苗病毒株相匹配。这些结果在假说的背景下进行了讨论，这些假说旨在解释痘苗病毒的未知来源，建议进一步研究以阐明传代正痘病毒的进化轨迹。