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Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis.
BMC Chemistry ( IF 4.6 ) Pub Date : 2020-04-22 , DOI: 10.1186/s13065-020-00685-3
Nan Zhang 1, 2 , Di Liu 1, 2 , Shuxiang Wei 1, 2 , Shijie Cao 1, 2 , Xinchi Feng 1 , Kai Wang 1 , Liqin Ding 1, 2 , Feng Qiu 1, 2
Affiliation  

Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl2-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity.

中文翻译:

七叶树种子中的苯乙醇糖苷。浙江。

从七叶树种子中分离出三种新的苯乙醇苷(1-3)和一种已知的类似物(4)。变种 浙江。据我们所知,这是从七叶树属中首次分离出苯乙醇糖苷,从而丰富了其化学成分。通过大量的NMR和HRESIMS数据以及与文献数据的比较来进行结构阐明。此后,测定分离的化合物对PC12细胞中CoCl 2诱导的细胞毒性的神经保护活性,化合物3表现出中等活性。
更新日期:2020-04-23
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