BACKGROUND Social functioning (SF), the ability to engage with life and fulfill roles may be a salient "patient important outcome" in addiction treatment. It is not known if medication-assisted treatment (MAT) impacts SF in opioid use disorder (OUD). There is a growing evidence to suggest that men and women are impacted differently by OUD. This study is the largest to date to study sex differences in OUD and explore associations between MAT and SF. METHODS Data were collected from 2736 participants with OUD, enrolled in MAT for varying lengths of time, in outpatient clinics across Ontario. SF was defined according to the Maudsley Addiction Profile's domains of (1) employment, (2) criminal activity, and (3) interpersonal conflict. Using logistic regression analysis, we examined sociodemographic and clinical factors associated with domains of SF. RESULTS There were 1544 men (56%) and 1192 women (44%) in this study, and ages varied from 17 to 76 years for men and 18 to 69 years for women. At study entry, participants had been on MAT for a median of 2 years. Compared to men, women reported more psychological (mean MAP score 14/40, SD = 9.55, versus 11/40, SD = 8.64; p < 0.001) and physical symptoms (mean MAP score 17/40, SD = 7.70 versus 14/40, SD = 7.74; p < 0.001). More women reported unemployment(74% versus 58%; p < 0.0001) and interpersonal conflict (46% versus 35%; p < 0.0001). Men were more likely than women to report criminal activity (11%, versus 8%; p = 0.001). Psychological symptoms increased the risk of worse SF, across domains, for men and for women. Every year on MAT was associated with a 7% increase in the odds of women engaging with criminal activity (OR = 1.07, 95% CI 1.02, 1.12, p = 0.006). CONCLUSIONS Men and women had different SF profiles and psychological symptoms scores while on MAT. The length of time on MAT increased the risk of criminal activity in women, and overall, duration of MAT was not associated with improvement in SF. This may suggest that MAT alone may not support continual improvements in SF in OUD.

中文翻译：

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接受阿片类药物使用障碍药物辅助治疗的男性和女性的社会功能结果。

背景技术社交功能（SF），与生活互动并履行角色的能力可能是成瘾治疗中的显着“患者重要结果”。尚不清楚药物辅助治疗（MAT）是否会影响阿片类药物使用障碍（OUD）中的SF。越来越多的证据表明，男人和女人会受到OUD的不同影响。这项研究是迄今为止最大的研究OUD中性别差异并探索MAT与SF之间关联的研究。方法在安大略省的门诊中，从2736名OUD参与者中收集了数据，他们参加了不同时间的MAT考试。SF是根据Maudsley上瘾概况的领域定义的，这些领域包括：（1）就业，（2）犯罪活动和（3）人际冲突。使用逻辑回归分析，我们研究了与SF域相关的社会人口统计学和临床​​因素。结果这项研究中有1544名男性（56％）和1192名女性（44％），男性的年龄从17岁到76岁不等，女性的年龄从18岁到69岁不等。在参加研究时，参与者参加MAT的平均时间为2年。与男性相比，女性的心理症状（平均MAP得分14/40，SD = 9.55，而11/40，SD = 8.64； p <0.001）和身体症状（平均MAP得分17/40，SD = 7.70 vs 14 /）。 40，SD ＝ 7.74； p ＜0.001）。报告失业的妇女人数更多（74％比58％； p <0.0001）和人际冲突（46％vs 35％； p <0.0001）。男性比女性更有可能报告犯罪行为（11％，相对于8％； p = 0.001）。心理症状增加了男性和女性跨领域SF恶化的风险。每年参加MAT考试的女性从事犯罪活动的几率都会增加7％（OR = 1.07，95％CI 1.02，1.12，p = 0.006）。结论男性和女性在使用MAT时有不同的SF特征和心理症状评分。服用MAT的时间长度增加了女性犯罪活动的风险，总体而言，MAT的持续时间与SF的改善无关。这可能表明仅MAT可能无法支持OUD中SF的持续改进。