Serotonin is crucial for proper foetal development, and the placenta has been described as a ‘donor’ of serotonin for the embryo/foetus. However, in later stages of gestation the foetus produces its own serotonin from maternally‐derived tryptophan and placental supply is no longer needed. We propose a novel model of serotonin homeostasis in the term placenta with special focus on the protective role of organic cation transporter 3 (OCT3/SLC22A3 ).

中文翻译：

---

足月母胎界面中的血清素稳态：转运蛋白（SERT/SLC6A4 和 OCT3/SLC22A3）和单胺氧化酶 A（MAO-A）在人和大鼠足月胎盘吸收和降解血清素中的作用。

血清素对胎儿的正常发育至关重要，胎盘被描述为胚胎/胎儿血清素的“供体”。然而，在妊娠后期，胎儿会从母源性色氨酸中产生自己的血清素，不再需要胎盘供应。我们提出了一种新的胎盘血清素稳态模型，特别关注有机阳离子转运蛋白 3 (OCT3/ SLC22A3 )的保护作用。