Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal epithelial cells are composed of different junctional molecules, such as claudin and occludin, and regulate the paracellular permeability of water, ions, and macromolecules in adjacent cells. One of the most important roles of the TJ structure is to provide a physical barrier to luminal inflammatory molecules. Impaired integrity and structure of the TJ barrier result in a forcible activation of immune cells and chronic inflammation in different tissues. According to recent studies, the intestinal TJ barrier could be regulated, as a potential target, by dietary factors to prevent and reduce different inflammatory disorders, although the precise mechanisms underlying the dietary regulation remain unclear. This review summarizes currently available information on the regulation of the intestinal TJ barrier by food components.

中文翻译：

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营养物质对肠道屏障的调节：紧密连接的作用。

紧密连接 (TJ) 在肠道屏障功能中起着重要作用。肠上皮细胞中的 TJ 由不同的连接分子组成，例如 claudin 和 occludin，并调节相邻细胞中水、离子和大分子的细胞旁通透性。TJ 结构最重要的作用之一是为管腔炎症分子提供物理屏障。TJ 屏障的完整性和结构受损会导致免疫细胞的强行激活和不同组织中的慢性炎症。根据最近的研究，肠道 TJ 屏障可以作为潜在目标通过饮食因素进行调节，以预防和减少不同的炎症性疾病，尽管饮食调节的确切机制仍不清楚。