The aims of this study were to investigate the effects of dietary supplementation with dihydroartemisinin (DHA) on growth performance, hepatic inflammation, and lipid metabolism in intrauterine growth retardation (IUGR)‐affected weaned piglets. Eight piglets with normal birth weight (NBW) and 16 IUGR‐affected piglets were selected and fed either a basal diet (NBW and IUGR groups) or the basal diet supplemented with 80 mg/kg DHA (IUGR‐DHA group) from 21 to 49 day of age. Blood and liver samples were collected on day 49. DHA supplementation significantly alleviated the compromised growth performance and liver damage in IUGR‐affected piglets. Additionally, DHA supplementation decreased the activities of alanine aminotransferase and aspartate aminotransferase, as well as the serum levels of non‐esterified fatty acids (NEFA), very‐low‐density lipoprotein, and total cholesterol. In the liver, the concentrations of interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, triglycerides, and NEFA were decreased. Fatty acid synthesis was decreased by DHA supplementation, whereas the activities of lipoprotein lipase, hepatic lipase, and total lipase were increased. Dietary DHA supplementation led to upregulation of the expression of AMPK/SIRT1 signaling pathway‐related genes, whereas that of inflammatory factor‐related genes were downregulated. In conclusion, dietary inclusion of 80 mg/kg DHA can alleviate IUGR‐induced impairments in piglets.

中文翻译：

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日粮中添加双氢青蒿素对宫内生长迟缓断奶仔猪生长性能、肝脏炎症和脂质代谢的影响。

本研究的目的是研究日粮中添加双氢青蒿素 (DHA) 对受宫内发育迟缓 (IUGR) 影响的断奶仔猪的生长性能、肝脏炎症和脂质代谢的影响。选择了 8 头正常出生体重 (NBW) 的仔猪和 16 头受 IUGR 影响的仔猪，喂养基础日粮（NBW 和 IUGR 组）或添加 80 mg/kg DHA 的基础日粮（IUGR-DHA 组），从 21 到 49 岁年龄的一天。在第 49 天收集血液和肝脏样本。补充 DHA 显着减轻了受 IUGR 影响的仔猪的生长性能受损和肝脏损伤。此外，补充 DHA 可降低丙氨酸氨基转移酶和天冬氨酸氨基转移酶的活性，以及​​非酯化脂肪酸 (NEFA) 的血清水平，极低密度脂蛋白和总胆固醇。在肝脏中，白细胞介素 1 β、白细胞介素 6、肿瘤坏死因子 α、甘油三酯和 NEFA 的浓度降低。补充 DHA 会降低脂肪酸合成，而脂蛋白脂肪酶、肝脂肪酶和总脂肪酶的活性会增加。膳食 DHA 补充剂导致 AMPK/SIRT1 信号通路相关基因表达上调，而炎症因子相关基因表达下调。总之，日粮中添加 80 mg/kg DHA 可以减轻 IUGR 引起的仔猪损伤。而脂蛋白脂肪酶、肝脂肪酶和总脂肪酶的活性增加。膳食 DHA 补充剂导致 AMPK/SIRT1 信号通路相关基因表达上调，而炎症因子相关基因表达下调。总之，日粮中添加 80 mg/kg DHA 可以减轻 IUGR 引起的仔猪损伤。而脂蛋白脂肪酶、肝脂肪酶和总脂肪酶的活性增加。膳食 DHA 补充剂导致 AMPK/SIRT1 信号通路相关基因表达上调，而炎症因子相关基因表达下调。总之，日粮中添加 80 mg/kg DHA 可以减轻 IUGR 引起的仔猪损伤。