Epilepsy is one of the most prevalent neurologic disorders, causing serious psychological problems and reducing quality of life. Although 20 different antiepileptic drugs (AEDs) have been approved by the US Food and Drug Administration (FDA), 30% of patients have drug‐resistant epilepsy (DRE). Considering the role of miR‐146a and miR‐134 in neuroinflammation and dendritic functionality, respectively, the aim of this study was the clinical evaluation of circulating miR‐146a and miR‐134 as novel noninvasive molecular markers for the prognosis of refractory epilepsy.

中文翻译：

---

循环 miR-146a 和 miR-134 预测局灶性意识障碍癫痫患者的耐药性癫痫

癫痫是最普遍的神经系统疾病之一，会导致严重的心理问题并降低生活质量。尽管美国食品和药物管理局 (FDA) 已批准了 20 种不同的抗癫痫药物 (AED)，但仍有 30% 的患者患有耐药性癫痫 (DRE)。考虑到 miR-146a 和 miR-134 分别在神经炎症和树突功能中的作用，本研究的目的是对循环 miR-146a 和 miR-134 作为难治性癫痫预后的新型无创分子标志物进行临床评估。