当前位置: X-MOL 学术Dev. Neurobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Initial axon growth rate from embryonic sensory neurons is correlated with birth date.
Developmental Neurobiology ( IF 3 ) Pub Date : 2020-04-21 , DOI: 10.1002/dneu.22743
Anthony R Horton 1 , Alun M Davies 1
Affiliation  

Axon growth rate from different populations of sensory neurons is correlated with the distance they have to grow to reach their targets in development: neurons with more distant targets extend axons at intrinsically faster rates. With growth of the embryo, later‐born neurons within each population have further to extend their axons to reach their targets than early‐born neurons. Here we examined whether the axon growth rate is related to birth date by studying the axon growth from neurons that differentiate in vitro from precursor cells isolated throughout the period of neurogenesis. We first showed that neurons that differentiated in vitro from different precursor cell populations exhibited differences in axon growth rate related to in vivo target distance. We then examined the axon growth rate from neurons that differentiate from the same precursor population at different stages throughout the period of neurogenesis. We studied the epibranchial placode precursors that give rise to nodose ganglion neurons in the chicken embryo. We observed a highly significant, threefold difference in axon growth rate from neurons that differentiate from precursor cells cultured early and late during the period of neurogenesis. Our findings suggest that intrinsic differences in axon growth rate are correlated with the neuronal birth date.

中文翻译:

胚胎感觉神经元的初始轴突生长速率与出生日期相关。

来自不同感觉神经元群体的轴突生长速度与它们必须生长以达到发育中的目标的距离相关:具有更远目标的神经元以本质上更快的速度延伸轴突。随着胚胎的生长,每个群体中晚出生的神经元比早出生的神经元需要进一步延伸它们的轴突以达到它们的目标。在这里,我们通过研究神经元的轴突生长来检查轴突生长速率是否与出生日期有关,这些神经元在体外与整个神经发生期间分离的前体细胞区分开来。我们首先表明,在体外从不同前体细胞群分化的神经元表现出与体内目标距离相关的轴突生长率差异。然后,我们检查了神经元的轴突生长速率,这些神经元在整个神经发生期间的不同阶段从相同的前体群体中分化出来。我们研究了鸡胚中产生结节神经节神经元的鳃外基板前体。我们观察到神经元的轴突生长速率存在高度显着的三倍差异,这些神经元与神经发生期间早期和晚期培养的前体细胞不同。我们的研究结果表明,轴突生长速率的内在差异与神经元出生日期相关。与在神经发生期间早期和晚期培养的前体细胞分化的神经元的轴突生长速率存在三倍差异。我们的研究结果表明,轴突生长速率的内在差异与神经元出生日期相关。与在神经发生期间早期和晚期培养的前体细胞分化的神经元的轴突生长速率存在三倍差异。我们的研究结果表明,轴突生长速率的内在差异与神经元出生日期相关。
更新日期:2020-04-21
down
wechat
bug