Within heterogeneous tumors, cancer cells are constantly interacting. Cell competition (CC) is a fitness-based selection mechanism that results in increased proliferation of discrete populations at the expense of their less fit neighbors. CC-based selection of fit cells may also drive selection of the most aggressive cancer cells.

中文翻译：

---

细胞竞争刺激了侵略性癌细胞的选择。

在异质性肿瘤中，癌细胞不断相互作用。细胞竞争（CC）是一种基于适应度的选择机制，该机制导致离散种群的增殖增加，但代价是邻居的适应度降低。基于CC的健康细胞选择也可能推动对最具攻击性的癌细胞的选择。