Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of applications, such as environmental, biomedical, pharmaceutical, agriculture and forensic medicine to name a few. Compared with Sanger sequencing, high-throughput sequencing technology has the advantages of larger output, high resolution, and low cost which greatly promotes the application of sequencing technology in life science research. Magnetic nanoparticles, as an important part of nanomaterials, have been widely used in various applications because of their good dispersion, high surface area, low cost, easy separation in buffer systems and signal detection. Based on the above, the application of magnetic nanoparticles in nucleic acid detection was reviewed.

中文翻译：

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磁性纳米粒子在核酸检测中的应用。

核酸是用于存储，复制和传输遗传信息的主要材料。基因测序在DNA损伤研究，基因治疗，突变分析，细菌感染，药物开发和临床诊断中具有重要意义。基因检测具有广泛的应用，例如环境，生物医学，制药，农业和法医学等等。与桑格测序相比，高通量测序技术具有产量大，分辨率高，成本低的优点，极大地促进了测序技术在生命科学研究中的应用。磁性纳米颗粒作为纳米材料的重要组成部分，因其分散性好，表面积大，成本低，在缓冲系统中易于分离和信号检测而被广泛用于各种应用中。