Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology.,Clinical Epigenetics

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Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology.
Clinical Epigenetics ( IF 5.7 ) Pub Date : 2020-04-21 , DOI: 10.1186/s13148-020-00849-x
Yuan-Yuan Gu ₁ , Guan-Nan Zhou _{1,

2} , Qing Wang ₁ , Jing-Xin Ding _{1,

2} , Ke-Qin Hua _{1,

2}

Affiliation

BACKGROUND Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cytology result ≥HSIL+ (high-grade squamous intraepithelial lesion or worse) were referred to colposcopy for pathological diagnosis. Methylation of S5 was quantified by pyrosequencing. RESULTS The S5 classifier separates women with ≥HSIL+ from

更新日期：2020-04-22

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