A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d6 by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.

中文翻译：

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氘标记的 DL-threo-thiamphenicol 的合成

描述了合成氘标记的噻吩菌素的一种方便且廉价的方法。DL-threo-Thiamphenicol-methyl-d3 是通过六步法从 4-溴苯甲醛和 DMSO-d6 开始，采用微波辅助铜介导的甲基硫醇化和改进的 Wulff 不对称氮丙啶化反应制备的，具有高化学纯度和同位素富集。