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Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination
Neuroscience Research ( IF 2.9 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.neures.2020.03.012
Magali Hernandez 1 , Guillaume Harlé 2 , Robert Lalonde 3 , Catherine Strazielle 1
Affiliation  

Glucocorticoids are involved in the developing brain but, in excessive amounts, may depress its growth and cause psychomotor development disorders. To test the long-term vulnerability of motor structures such as the cerebellum to supraphysiological corticosterone (CORT), the hormone was subcutaneously delivered at a dose of 20 mg/kg from postnatal day (P) 8 to P29 in C57BL/6 male mice evaluated for sensorimotor functions at P15, P22, P29, and 3 months. Relative to placebo, CORT increased motor activity in the open-field at P29 and 3 months as well as facilitating rotorod acquisition and visuomotor control necessary for swimming towards a visible goal without affecting spatial learning in the Morris water maze. CORT caused lobule-specific effects on cerebellar morphology by decreasing granule cell layer thickness in simplex lobule but increasing molecular and granule cell layer thickness in crus 2. The functional impact of these changes is indicated by significant correlations found between cerebellar size and activity levels or proficiency on the rotorod test of motor coordination.

中文翻译:

皮质酮注射对中晚期小鼠出生后发育对成年运动活动和协调性的影响

糖皮质激素参与发育中的大脑,但过量使用可能会抑制其生长并导致精神运动发育障碍。为了测试运动结构(如小脑)对超生理皮质酮 (CORT) 的长期脆弱性,在评估的 C57BL/6 雄性小鼠中,从出生后第 8 天 (P) 到 P29 以 20 mg/kg 的剂量皮下递送激素P15、P22、P29 和 3 个月时的感觉运动功能。相对于安慰剂,CORT 在 P29 和 3 个月时增加了开放领域的运动活动,并促进了向可见目标游泳所需的旋转棒获取和视觉运动控制,而不会影响莫里斯水迷宫中的空间学习。
更新日期:2020-04-01
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