AIM We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center. METHOD Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of orthostatic intolerance associated with excessive orthostatic tachycardia as determined by tilt table testing with orthostatic heart rate increment of ≥40 bpm within 5 minutes of head-up tilt or absolute orthostatic heart rate ≥130 bpm for patients 13 years old and younger and ≥120 bpm for those 14 years and older. We looked at demographics, presenting symptoms, comorbidities, examination findings, investigation findings, treatment, and patient reported outcomes. Outcome measures were separated by patient report and group comparisons were made using 2-sample t tests or Mann-Whitney U tests for continuous variables and Fisher exact tests for categorical variables. RESULTS One hundred thirty-four patients with pediatric onset POTS were identified. The mean age was 15 years. Seventy-nine percent of patients were female and 90% were white. The most common presenting symptoms included dizziness/lightheadedness (88%), syncope (54%), and palpitations (40%). Many patients had significant comorbidities attributable to numerous bodily systems, most commonly headache syndromes (migraine 43%, nonspecific headache 22%, chronic daily headache 14%, and new daily persistent headache 5%) and chronic fatigue (60%). Low vitamin D and insufficient iron stores were commonly seen. The majority of patients improved or had resolution of symptoms following treatment (70%). When separated by outcome, statistically significant differences were found for glucose (patients whose symptoms resolved had higher median glucose), palpitations (patients whose symptoms resolved were less likely to have palpitations), constipation (patients whose symptoms were stable/worsened were more likely to have constipation), and unexplained pain (patients whose symptoms were stable/worsened were more likely to have unexplained pain). CONCLUSIONS Pediatric POTS is a chronic condition with a fairly good prognosis following appropriate treatment. It is associated with numerous comorbidities that necessitate multidisciplinary expert care.

中文翻译：

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单一三级护理中心的儿科起病体位性直立性心动过速综合征。

目的 我们描述了在单一三级保健转诊中心看到的儿科体位性直立性心动过速综合征 (POTS) 人群的特征。方法 对 2015 年至 2017 年期间在我们中心就诊的所有儿科 POTS 患者进行回顾性图表审查。 儿科 POTS 被定义为至少 3 个月的慢性体位性不耐受症状，与体位性心率增加的倾斜台测试确定的过度体位性心动过速相关13 岁及以下患者在抬头倾斜 5 分钟内≥40 bpm 或绝对直立心率≥130 bpm，14 岁及以上患者≥120 bpm。我们查看了人口统计学、症状、合并症、检查结果、调查结果、治疗和患者报告的结果。结果测量由患者报告分开，组比较使用连续变量的 2 样本 t 检验或 Mann-Whitney U 检验和分类变量的 Fisher 精确检验进行。结果 确定了 134 名儿科发作的 POTS 患者。平均年龄为 15 岁。79% 的患者是女性，90% 是白人。最常见的症状包括头晕/头晕 (88%)、晕厥 (54%) 和心悸 (40%)。许多患者有明显的合并症，可归因于多种身体系统，最常见的是头痛综合征（偏头痛 43%，非特异性头痛 22%，慢性每日头痛 14%，新的每日持续性头痛 5%）和慢性疲劳（60%）。常见的维生素 D 低和铁储备不足。大多数患者在治疗后症状有所改善或消退（70%）。当按结果分开时，发现血糖（症状缓解的患者的中位血糖值较高）、心悸（症状缓解的患者不太可能出现心悸）、便秘（症状稳定/恶化的患者更可能出现心悸）存在统计学显着差异。有便秘）和不明原因的疼痛（症状稳定/恶化的患者更有可能出现不明原因的疼痛）。结论 小儿 POTS 是一种慢性病，经过适当治疗后预后相当好。它与许多需要多学科专家护理的合并症有关。在血糖（症状缓解的患者血糖中位数更高）、心悸（症状缓解的患者不太可能出现心悸）、便秘（症状稳定/恶化的患者更可能出现便秘）和不明原因的疼痛（症状稳定/恶化的患者更有可能出现不明原因的疼痛）。结论 小儿 POTS 是一种慢性病，经过适当治疗后预后相当好。它与许多需要多学科专家护理的合并症有关。在血糖（症状缓解的患者血糖中位数更高）、心悸（症状缓解的患者不太可能出现心悸）、便秘（症状稳定/恶化的患者更可能出现便秘）和不明原因的疼痛（症状稳定/恶化的患者更有可能出现不明原因的疼痛）。结论 小儿 POTS 是一种慢性病，经过适当治疗后预后相当好。它与许多需要多学科专家护理的合并症有关。便秘（症状稳定/恶化的患者更可能出现便秘）和不明原因的疼痛（症状稳定/恶化的患者更可能出现不明原因的疼痛）。结论 小儿 POTS 是一种慢性病，经过适当治疗后预后相当好。它与许多需要多学科专家护理的合并症有关。便秘（症状稳定/恶化的患者更可能出现便秘）和不明原因的疼痛（症状稳定/恶化的患者更可能出现不明原因的疼痛）。结论 小儿 POTS 是一种慢性病，经过适当治疗后预后相当好。它与许多需要多学科专家护理的合并症有关。