OBJECTIVE To describe systematic reviews (SRs) of the use of exoskeletons for gait and mobility by persons with neurologic disorders and to evaluate their quality as guidance for research and clinical practice. DATA SOURCES PubMed, EMBASE, Web of Science, CINAHL Complete, PsycINFO, Cochrane Database of Systematic Reviews, PEDro, and Google Scholar were searched from database inception to January 23, 2018. STUDY SELECTION A total of 331 deduplicated abstracts from bibliographic database and ancestor searching were independently screened by 2 reviewers, resulting in 109 articles for which full text was obtained. Independent screening of those 109 articles by 2 reviewers resulted in a final selection of 17 SRs. DATA EXTRACTION Data were extracted by 1 reviewer using a pretested Excel form with 158 fields and checked by a second reviewer. Key data included the purpose of the SR, methods used, outcome measures presented, and conclusions. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses and A MeaSurement Tool to Assess Systematic Reviews version 2 were used to evaluate reporting and methodological quality, respectively, of the SRs. DATA SYNTHESIS The SRs generally were of poor methodological and reporting quality. They failed to report some information on patients (eg, height, weight, baseline ambulatory status) and interventions (eg, treatment hours or sessions planned and delivered) that clinicians and other stakeholders might want to have, and often failed to notice that the primary studies duplicated subjects. CONCLUSIONS Published SRs on exoskeletons have many weaknesses in design and execution; clinicians, researchers, and other stakeholders should be cautious in relying on them to make decisions on the use of this technology. Future primary and secondary studies need to address the multiple methodological limitations.

中文翻译：

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外骨骼用于神经系统疾病步态和活动能力的临床益处的系统评价：一项三级研究

目的 描述神经系统疾病患者使用外骨骼进行步态和活动能力的系统评价 (SR)，并评估其质量，作为研究和临床实践的指导。数据来源 PubMed、EMBASE、Web of Science、CINAHL Complete、PsycINFO、Cochrane Database of Systematic Reviews、PEDro 和 Google Scholar 的检索时间从数据库开始到 2018 年 1 月 23 日。 研究选择 来自书目数据库和祖先的总共 331 份去重摘要检索由2名审稿人独立筛选，得到全文109篇。2 位审稿人对这 109 篇文章进行了独立筛选，最终选出了 17 篇 SR。数据提取 数据由 1 位审阅者使用具有 158 个字段的预先测试的 Excel 表格提取，并由第二位审阅者检查。关键数据包括 SR 的目的、使用的方法、呈现的结果测量和结论。系统评价和元分析的首选报告项目和系统评价评估工具第 2 版分别用于评估 SR 的报告和方法学质量。数据综合 SR 的方法和报告质量一般都很差。他们未能报告一些临床医生和其他利益相关者可能希望获得的患者信息（例如，身高、体重、基线动态状态）和干预措施（例如，计划和实施的治疗时间或疗程），并且经常没有注意到主要研究重复的科目。结论 已发表的关于外骨骼的 SR 在设计和执行方面存在许多弱点；临床医生、研究人员、和其他利益相关者在依赖他们就使用该技术做出决定时应谨慎。未来的主要和次要研究需要解决多种方法学限制。