Background: For many biomarkers in cardiac surgery, there is a lack of knowledge regarding the normal dynamics of plasma levels during the perioperative course. The aim of this study was to investigate the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP and sP-selectin in cardiac surgery.Method: A prospective observational pilot study with 20 patients scheduled for open cardiac surgery procedures with cardiopulmonary bypass (CPB). Plasma samples were taken for each patient and biomarker during the pre-, per- and postoperative period until Day 6 postoperatively.Results: MR-proADM increased significantly from 0.62 [IQR; 0.54-0.93] nmol/L preoperatively to 1.20 [1.04-1.80] nmol/L postoperative Day 1. MR-proANP increased significantly from 125 [77-152] pmol/L preoperatively to 198 [168-307] pmol/L on weaning from CPB. hs-CRP increased significantly from 2.5 mg/L [0.4-12] preoperatively to peak at 208 mg/L [186-239] postoperative Day 3. The preoperative level of sP-selectin at 23.0 [21.3-26.3] ng/mL initially fell at weaning from CPB, followed by a significant peak of 25.5 [22.7-27.7] ng/mL 8 h postoperatively.Conclusions: The findings in this study may help to understand the physiology of the biomarkers analysed and their response to cardiac surgical trauma including CPB. Furthermore, these findings will guide us in further research on the clinical usefulness of these biomarkers.

中文翻译：

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心脏手术中的生物标记动力学：围手术期对MR-proADM，MR-proANP，hs-CRP和sP-选择素血浆水平的前瞻性观察研究。

背景：对于心脏外科手术中的许多生物标志物，围手术期过程中缺乏有关血浆水平正常动态的知识。本研究旨在探讨MR-proADM，MR-proANP，hs-CRP和sP-选择素在心脏手术中的围手术期动态。 （CPB）。在术前，术前和术后直至术后第6天，为每位患者和生物标记物采集血浆样品。结果：MR-proADM从0.62显着增加[IQR；术前0.54-0.93] nmol / L，术后第1天为1.20 [1.04-1.80] nmol / L。断奶前MR-proANP从术前的125 [77-152] pmol / L显着增加至198 [168-307] pmol / L来自CPB。术后第3天hs-CRP从术前的2.5 mg / L [0.4-12]显着增加至208 mg / L [186-239]的峰值。术前sP-selectin的水平最初为23.0 [21.3-26.3] ng / mL断奶后CPB下降，随后在术后8 h达到25.5 [22.7-27.7] ng / mL的显着峰值。结论：本研究的发现可能有助于了解所分析生物标志物的生理学及其对心脏手术创伤的反应，包括CPB。此外，这些发现将指导我们进一步研究这些生物标志物的临床实用性。这项研究的发现可能有助于了解所分析生物标志物的生理学及其对心脏外科创伤（包括CPB）的反应。此外，这些发现将指导我们进一步研究这些生物标志物的临床实用性。这项研究的发现可能有助于了解所分析生物标志物的生理学及其对心脏外科创伤（包括CPB）的反应。此外，这些发现将指导我们进一步研究这些生物标志物的临床实用性。