Stroke is one of the major causes of lethality and disability, yet few effective therapies have been established for ischemic stroke. Inflammation in the ischemic brain is induced by the infiltration and subsequent activation of immune cells. Loss of cerebral blood flow and ischemic brain-cell death trigger the activation of infiltrating immune cells and drastic changes in the lipid content of the ischemic brain. In particular, polyunsaturated fatty acids and their metabolites regulate cerebral post-ischemic inflammation and ischemic stroke pathologies. In this review, we discuss the relationships between the lipid mediators and cerebral post-ischemic inflammation and their relevance to possible future therapeutic strategies targeting lipid mediators for ischemic stroke.

中文翻译：

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缺血性中风中的脂质介质和无菌炎症。

中风是致死和致残的主要原因之一，但很少有针对缺血性中风的有效疗法。缺血脑的炎症是由免疫细胞的浸润和随后的激活引起的。脑血流减少和缺血性脑细胞死亡会触发浸润性免疫细胞的激活和缺血性脑脂质含量的剧烈变化。特别是，多不饱和脂肪酸及其代谢物调节脑缺血后炎症和缺血性中风病理。在这篇综述中，我们讨论了脂质介质与脑缺血后炎症之间的关系，以及它们与未来可能针对缺血性卒中脂质介质的治疗策略的相关性。