Aim: The aim of this project is to improve the therapeutic effectiveness, permeation and retention of clobetasol propionate in sebaceous glands by reporting the use of Squarticles as lipidic nanosystem.

Methods: Homogenisation method is used for the formulation of Squarticles (nanoemulgel) which was characterised on the basis of size, polydispersity index (PDI), viscosity, spreadability, DSC, % in vitro release, in vitro skin permeation deposition studies, and in vivo studies, scanning electron microscopic (SEM) and physical storage stability studies were done at different temperature conditions, i.e. 4 ± 2 °C, 25 ± 2 °C and 45 ± 2 °C for a period of 6 months for drug and formulation.

Result: The morphological characterisation of prepared nanoemulsion shows small spherical shape and uniform size distribution as observed in the Scanning electron microscopic (SEM), having mean size (240.5 ± 9.2) and mean size distribution (0.282 ± 0.03) and zeta potential (−51.21). The drug release from optimised nanoemulsion (F2) in PBS (pH 5.5) was approximately 84.24 ± 1.35%, nanoemulgel formulations showed the release of 66.83 ± 2.05% while marketed gel showed the release of 57.67 ± 1.63% after 24 h. The cumulative percentage retention of clobetasol propionate loaded nanoemulgel was 63 ± 1.28% which was more than the marketed formulation (23.12% ±0.54). Physical stability studies show that formulation is more stable in cold condition. Further, the stability of active ingredient in gel formulation was determined using HPLC which shows around 15 ± 0.84% of loss in its activity.

Conclusion: The present work has demonstrated the use of Squarticles as a novel carrier for treatment of plaque psoriasis by enhancing the better permeation, increasing skin retention, and enhances the effect of drug. The study also shows that the formulation is more stable in cold condition

目的：该项目的目的是通过报道将小方糖用作脂质纳米系统来提高皮脂腺中丙酸氯倍他索的治疗效果，渗透性和保留率。

方法：均质化方法用于制备方鳞片（纳米乳胶），根据大小，多分散指数（PDI），粘度，铺展性，DSC，体外释放百分数，体外皮肤渗透沉积研究和体内特性来表征在不同的温度条件下（即4±2°C，25±2°C和45±2°C）对药物和制剂进行了6个月的研究，扫描电子显微镜（SEM）和物理存储稳定性研究。

结果：如在扫描电子显微镜（SEM）中观察到的，所制备的纳米乳液的形态表征显示出小的球形和均匀的尺寸分布，具有平均尺寸（240.5±9.2）和平均尺寸分​​布（0.282±0.03）和ζ电势（-51.21）。在PBS（pH 5.5）中，优化的纳米乳（F2）释放的药物约为84.24±1.35％，纳米乳凝胶制剂显示24.h后释放66.83±2.05％，而市售凝胶显示释放57.67±1.63％。丙酸氯倍他索负载的纳米乳剂的累积保留百分率为63±1.28％，高于市售制剂（23.12％±0.54）。物理稳定性研究表明，制剂在寒冷条件下更稳定。此外，使用HPLC确定了凝胶制剂中活性成分的稳定性，显示15±0左右。

结论：目前的工作已经证明，Squaarticles可作为新型载体用于治疗斑块状牛皮癣，可增强渗透性，增加皮肤保留力并增强药物治疗效果。研究还表明该制剂在寒冷条件下更稳定