Background Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-α) plays an important role in inflammation. Several studies have focused on the association between TNF-α polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-α rs1800629 (− 308 G/A), rs361525 (− 238 G/A) and rs1799724 polymorphisms and prostate cancer risk. Methods Eligible studies were identified from electronic databases (PubMed, Embase, Wanfang and CNKI) using keywords: TNF-α, polymorphism, prostate cancer, until Nov 15, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to determine the association from a quantitative point-of-view. Publication bias and sensitivity analysis were also applied to evaluate the power of current study. All statistical analyses were done with Stata 11.0 software. Results Twenty-two different articles were included (22 studies about rs1800629; 8 studies for rs361525 and 5 studies related to rs1799724). Overall, no significant association was found between rs1800629 and rs1799724 polymorphisms and the risk of prostate cancer in the whole (such as: OR = 1.03, 95% CI = 0.92–1.16, P = 0.580 in the allele for rs1800629; OR = 0.95, 95% CI = 0.84–1.07, P = 0.381 in the allele for rs1799724). The rs361525 polymorphism also had no association with prostate cancer in the cases (OR = 0.93, 95% CI = 0.66–1.32, P = 0.684 in the allele) and ethnicity subgroup. The stratified subgroup of genotype method, however, revealed that the rs361525 variant significantly decreased the risk of prostate cancer in the Others (OR = 0.65, 95% CI = 0.47–0.89, P = 0.008, A-allele vs G-allele) and PCR-RFLP (OR = 2.68, 95% CI = 1.00–7.20, P = 0.050, AG vs GG or AA+AG vs GG) methods. Conclusions In summary, the findings of the current meta-analysis indicate that the TNF-α rs1800629, rs361525 and rs1799724 polymorphisms are not correlated with prostate cancer development, although there were some pooled positive results. Further well-designed studies are necessary to form more precise conclusions.

中文翻译：

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肿瘤坏死因子-α 基因的三种多态性（rs1800629、rs361525 和 rs1799724）与前列腺癌易感性之间没有关联：综合荟萃分析

背景炎症是与前列腺癌相关的因素之一。细胞因子肿瘤坏死因子-α (TNF-α) 在炎症中起重要作用。几项研究集中在 TNF-α 多态性与前列腺癌发展之间的关联。我们的荟萃分析旨在估计 TNF-α rs1800629 (- 308 G/A)、rs361525 (- 238 G/A) 和 rs1799724 多态性与前列腺癌风险之间的关联。方法 使用关键词：TNF-α、多态性、前列腺癌，从电子数据库（PubMed、Embase、Wanfang 和 CNKI）中确定符合条件的研究，直到 2019 年 11 月 15 日。应用具有 95% 置信区间 (CI) 的优势比 (OR)从定量的角度确定关联。发表偏倚和敏感性分析也用于评估当前研究的效力。所有统计分析均使用Stata 11.0软件完成。结果 纳入了 22 篇不同的文章（22 篇关于 rs1800629 的研究；8 篇关于 rs361525 的研究和 5 篇与 rs1799724 相关的研究）。总体而言，rs1800629 和 rs1799724 多态性与整体前列腺癌风险之间未发现显着关联（例如：OR = 1.03，95% CI = 0.92–1.16，rs1800629 等位基因 P = 0.580；OR = 0. 95% CI = 0.84–1.07，在 rs1799724 的等位基因中 P = 0.381）。rs361525 多态性在病例（OR = 0.93，95% CI = 0.66–1.32，等位基因 P = 0.684）和种族亚组中也与前列腺癌无关。然而，基因型方法的分层亚组显示，rs361525 变异显着降低了其他人患前列腺癌的风险（OR = 0.65，95% CI = 0.47–0.89，P = 0.008，A-等位基因与 G-等位基因）和 PCR-RFLP（OR = 2.68，95% CI = 1.00–7.20，P = 0.050，AG 与 GG 或 AA+AG 与 GG）方法。结论 总之，当前荟萃分析的结果表明 TNF-α rs1800629、rs361525 和 rs1799724 多态性与前列腺癌的发展无关，尽管有一些汇总的阳性结果。需要进一步精心设计的研究以形成更精确的结论。