In this study, the surfaces of Ti–Ag casting alloys were modified by chemical treatment (acid etching combined with alkaline treatment) to produce hybrid micron and submicron porosities, sponge-like nanostructures and Ag-containing particles. The surface characteristics, ion release, pH values, antibacterial activities and cell responses of the chemically treated Ti–Ag (Ti–Ag(CT)) samples were investigated. The antibacterial activities of the Ti–Ag(CT) samples were assessed using Staphylococcus aureus, and these samples showed strong antibacterial activities that were attributed to Ag ion release and Ag-containing particles. The effects of Ti–Ag(CT) samples on cells were assessed using MC3T3-E1 mouse preosteoblasts; samples with 1 and 3 wt.% Ag showed higher cell adhesion and higher alkaline phosphatase values than those of commercially available pure Ti samples. These results indicated that Ti–Ag casting alloys with 1 and 3 wt.% Ag modified by chemical treatment prevented bacterial infection and have latent capacities to promote osseointegration.

在这项研究中，Ti-Ag 铸造合金的表面通过化学处理（酸蚀结合碱处理）进行改性，以产生混合微米和亚微米孔隙、海绵状纳米结构和含银颗粒。研究了化学处理的 Ti-Ag (Ti-Ag(CT)) 样品的表面特性、离子释放、pH 值、抗菌活性和细胞反应。使用金黄色葡萄球菌评估 Ti-Ag(CT) 样品的抗菌活性，并且这些样品显示出强抗菌活性，这归因于银离子释放和含银颗粒。使用 MC3T3-E1 小鼠前成骨细胞评估 Ti-Ag(CT) 样品对细胞的影响；与市售纯钛样品相比，含 1 和 3 wt.% Ag 的样品显示出更高的细胞粘附和更高的碱性磷酸酶值。这些结果表明，通过化学处理改性的含 1 和 3 wt.% Ag 的 Ti-Ag 铸造合金可防止细菌感染并具有促进骨整合的潜在能力。