Historical theories of metastasis have been informed by the seed and soil hypothesis, the Halsteadian paradigm proposing an orderly spread from local to distant sites, and the presumption that cancer is an inherently systemic process even in the earliest cases. The more contemporary spectrum theory now suggests that the propensity for distant spread exists along a continuum of metastatic virulence. Tumors with limited metastatic potential represent one subset along this spectrum that could potentially be cured with local ablative therapy. Integrating clinical and molecular features to biologically inform the classification of not only oligometastatic or oligoprogressive disease but also the entire metastatic spectrum holds great promise to improve prognostication and inform clinical decision making. To this end, the inclusion of molecular correlative studies and biospecimen collection on prospective protocols is imperative.

中文翻译：

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定义，生物学和低聚和寡进展性疾病的历史。

转移的历史理论已经得到了种子和土壤假说的启发，Halsteadian范式提出了从局部到远处有序扩散的假设，甚至在最早的病例中也认为癌症是固有的系统性过程。现在更现代的频谱理论表明，远距离传播的倾向沿着转移毒力的连续性存在。转移潜能有限的肿瘤代表了这一谱图中的一个子集，可以通过局部消融治疗治愈。整合临床和分子特征，以生物学方式告知寡转移或少进展疾病的分类，而且整个转移范围都有望改善预后并为临床决策提供依据。为此，