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Pregnancy outcomes in women with history of surgery for endometriosis
Fertility and Sterility ( IF 6.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.fertnstert.2019.12.037
Marilena Farella 1 , Isabella Chanavaz-Lacheray 2 , Eric Verspick 3 , Benjamin Merlot 2 , Clemence Klapczynski 3 , Clotilde Hennetier 3 , Jean-Jacques Tuech 4 , Horace Roman 5
Affiliation  

OBJECTIVE To assess the relationship between history of surgery for endometriosis and adverse obstetrical outcomes. DESIGN Retrospective study using prospectively recorded data. SETTING Referral center. PATIENT(S) Total of 569 women with history of surgery for endometriosis, postoperative conception, and pregnancy evolution over 22 weeks of gestation. INTERVENTIONS(S) Surgery for endometriosis. MAIN OUTCOME MEASURE(S) Small for gestational age (SGA) status of the newborn, spontaneous preterm birth (PT, before 37 weeks' gestation), and placenta previa. RESULTS Among 733 pregnancies included in the study, 566 deliveries were recorded (77.2%), of which 535 were singleton (72.9% of pregnancies) and 31 twins (4.2%). SGA was observed in 81 of 535 (15.1%) singleton pregnancies and in 9 of 31 (29%) twin pregnancies. PT occurred in 53 of 535 (9.9%) singleton pregnancies and in 19 of 31 (61.2%) twin pregnancies. The number of singleton and multiple pregnancies complicated by placenta previa were, respectively, 9 of 535 (1.7%) and 0 of 31. The independent factor found to relate to SGA was the absence of endometriomas; conception with the use of assisted reproductive technologies (ART) only tended toward statistical significance. Independent factors found to increase risk of PT were conception with the use of ART, body mass index >30 kg/m2, and surgery of deep endometriosis infiltrating the rectum and the bladder. Independent factors associated with placenta previa were conception with the use of ART and history of stage III or IV endometriosis. CONCLUSION(S) The risk of SGA and PT is increased in women with a history of surgery for endometriosis, and a high rate of conception with the use of ART may jeopardize outcomes.

中文翻译:

有子宫内膜异位症手术史女性的妊娠结局

目的 评估子宫内膜异位症手术史与不良产科结局之间的关系。设计 使用前瞻性记录数据的回顾性研究。设置推荐中心。PATIENT(S) 总共 569 名有子宫内膜异位症手术史、术后受孕和妊娠 22 周内妊娠演变的女性。INTERVENTIONS(S) 子宫内膜异位症手术。主要结局指标 新生儿的小于胎龄 (SGA) 状态、自发性早产(PT,妊娠 37 周前)和前置胎盘。结果 在纳入研究的 733 次怀孕中,记录了 566 次分娩 (77.2%),其中 535 次为单胎 (72.9% 的妊娠) 和 31 次双胞胎 (4.2%)。在 535 例 (15.1%) 单胎妊娠中的 81 例和 31 例 (29%) 双胎妊娠中有 9 例观察到 SGA。PT 发生在 535 次中的 53 次 (9. 9%) 单胎妊娠和 31 次 (61.2%) 双胎妊娠中的 19 次。单胎妊娠和多胎妊娠合并前置胎盘的数量分别为 535 例中的 9 例 (1.7%) 和 31 例中的 0 例。使用辅助生殖技术 (ART) 的概念仅趋于统计显着性。发现增加 PT 风险的独立因素是使用 ART 受孕、体重指数 >30 kg/m2 以及浸润直肠和膀胱的深部子宫内膜异位症的手术。与前置胎盘相关的独立因素是使用 ART 受孕以及 III 期或 IV 期子宫内膜异位症的病史。结论(S)有子宫内膜异位症手术史的女性发生 SGA 和 PT 的风险增加,
更新日期:2020-05-01
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