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Lipase Treatment of Dietary Krill Oil, but Not Fish Oil, Enables Enrichment of Brain Eicosapentaenoic Acid and Docosahexaenoic Acid.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-05-04 , DOI: 10.1002/mnfr.202000059
Poorna C R Yalagala 1 , Dhavamani Sugasini 1 , Steve B Zaldua 2 , Leon M Tai 2 , Papasani V Subbaiah 1, 3
Affiliation  

Currently available omega‐3 fatty acid supplements do not enrich the docosahexaenoic acid (DHA) of the adult brain because they are absorbed as triacylglycerol, whereas the transporter at the blood brain barrier requires lysophosphatidylcholine (LPC)‐DHA. The hypothesis that treatment of krill oil (KO), which contains DHA/eicosapentaenoic acid (EPA) at the SN2 position of phosphatidylcholine, with SN1‐specific lipase will generate LPC‐DHA/EPA and which can be absorbed intact and transported into the brain, is tested.

中文翻译:

膳食磷虾油而非鱼油的脂肪酶处理能够富集脑二十碳五烯酸和二十二碳六烯酸。

目前可用的 omega-3 脂肪酸补充剂不能丰富成人大脑的二十二碳六烯酸 (DHA),因为它们以三酰甘油的形式被吸收,而血脑屏障的转运蛋白需要溶血磷脂酰胆碱 (LPC)-DHA。假设用 SN1 特异性脂肪酶处理在磷脂酰胆碱的 SN2 位置含有 DHA/二十碳五烯酸 (EPA) 的磷虾油 (KO) 会产生 LPC-DHA/EPA,并且可以完整地吸收并转运到大脑,进行了测试。
更新日期:2020-05-04
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