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Biological behaviour and clinical outcome in 42 cats with sarcoids (cutaneous fibropapillomas).
Veterinary and Comparative Oncology ( IF 2.1 ) Pub Date : 2020-04-17 , DOI: 10.1111/vco.12598
Christopher J Wood 1 , Laura E Selmic 2 , Ariel N Schlag 3 , Cynthia Bacmeister 4 , Bernard Séguin 5 , William T N Culp 6 , Sara A Ayres 7 , Julia P Sumner 8 , Brittney Byer 5 , Ursula K Mayer 9 , Julius M Liptak 1
Affiliation  

Feline sarcoids (or cutaneous fibropapillomas) are rare dermal neoplasms. There are currently no reported statistics concerning their clinical behaviour. Our objective with this retrospective, multi‐institutional study was to describe the clinical presentation and biological behaviour of sarcoids in cats and to determine the oncologic outcome following surgical resection. Medical records from a laboratory database and six contributing institutions were searched to identify cats with histologically confirmed sarcoids. Forty‐two cats were included in the study. The majority of sarcoids occurred on the face, particularly rostral locations such as the lips and nasal planum. Complete and incomplete histologic excision was achieved in 18 and 21 cats, respectively. The overall local recurrence rate was 40.5%. Complete histologic excision was associated with a significantly lower local recurrence rate (11.1%) and longer disease‐free interval (not reached) compared with cats with incompletely excised sarcoids (66.7% and 250 days, respectively). The 1‐ and 2‐year local recurrence rates were 0% and 7%, respectively, for cats with complete histologic excision, and 67% at both time intervals for cats with incomplete histologic excision. Five of the cats (83.3%) treated with curative‐intent surgical revision following local tumour recurrence had no further local recurrence. All cats that died secondary to tumour‐related causes had initial incomplete histologic excision and were euthanized because of local recurrence. Wide surgical resection of feline sarcoids is recommended to achieve complete histologic excision, local tumour control and a potential cure. For cats with incomplete histologic excision or local tumour recurrence, repeat surgical resection is recommended.

中文翻译:

42 只患有肉瘤(皮肤纤维乳头状瘤)的猫的生物学行为和临床结果。

猫肉瘤(或皮肤纤维乳头状瘤)是罕见的皮肤肿瘤。目前尚无关于其临床行为的报告统计数据。我们进行这项回顾性多机构研究的目的是描述猫肉瘤的临床表现和生物学行为,并确定手术切除后的肿瘤学结果。搜索了来自实验室数据库和六个参与机构的医疗记录,以识别具有组织学证实的结节病的猫。研究中包括了 42 只猫。大多数肉瘤发生在面部,特别是嘴部位置,如嘴唇和鼻平面。分别在 18 和 21 只猫中实现了完全和不完全的组织学切除。整体局部复发率为40.5%。与结节不完全切除的猫(分别为 66.7% 和 250 天)相比,完全组织学切除与显着较低的局部复发率(11.1%)和更长的无病间隔(未达到)相关。组织学完全切除的猫的 1 年和 2 年局部复发率分别为 0% 和 7%,组织学切除不完全的猫在两个时间间隔内的局部复发率均为 67%。在局部肿瘤复发后接受治愈性手术翻修治疗的猫中有 5 只 (83.3%) 没有进一步的局部复发。所有继发于肿瘤相关原因死亡的猫最初都进行了不完全的组织学切除,并因局部复发而被安乐死。建议对猫肉瘤进行广泛的手术切除,以实现完整的组织学切除、局部肿瘤控制和潜在的治愈。
更新日期:2020-04-17
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