Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

中文翻译：

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胶质母细胞瘤中多方面的转化生长因子-β（TGFβ）信号传导。

胶质母细胞瘤 (GBM) 是一种侵袭性和破坏性的原发性脑癌，对治疗的反应非常差。患者的平均生存时间从诊断开始只有 14-15 个月，因此对于开发新型靶向疗法以改善患者预后存在明确且未满足的需求。多功能细胞因子 TGFβ 在发育、成体组织稳态、组织伤口修复和免疫反应中起着重要作用。TGFβ 信号传导的功能障碍与包括 GBM 在内的许多肿瘤类型的发展和进展有关，从而可能为其治疗提供可操作的靶点。本综述将研究 TGFβ 信号传导机制及其在 GBM 发生和进展中的作用。