Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the malignancy. Recently, through modulating cancer-associated fibroblasts (CAFs) which are the most abundant cell type among all stromal cells, natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells, showing promising ability to improve treatment effects on desmoplastic tumors. In this review, we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products, highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment.

增生性肿瘤具有大量的基质细胞和细胞外基质，通常会导致治疗耐药性。用于增生性肿瘤的当前治疗处方通常不足以消除恶性肿瘤。近来，通过调节在所有基质细胞中最丰富的细胞类型的癌症相关成纤维细胞（CAF），天然产物具有改善的化学疗法和将纳米药物递送至肿瘤细胞，显示出改善对增生性肿瘤的治疗效果的有希望的能力。在这篇综述中，我们讨论了通过使用天然产物对CAF建模来抑制增生性肿瘤的最新进展，重点介绍了天然产物靶向CAF的潜在治疗能力。