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Targeting neurotrophic factors: Novel approaches to musculoskeletal pain.
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2020-04-18 , DOI: 10.1016/j.pharmthera.2020.107553
Anne-Marie Malfait 1 , Rachel E Miller 1 , Joel A Block 1
Affiliation  

Chronic pain represents a substantial unmet medical need globally. In recent years, the quest for a new generation of novel, safe, mechanism-based analgesic treatments has focused on neurotrophic factors, a large group of secreted proteins that control the growth and survival of different populations of neurons, but that postnatally are involved in the genesis and maintenance of pain, with biological activity in both the periphery and the central nervous system. In this narrative review, we discuss the two families of neurotrophic proteins that have been extensively studied for their role in pain: first, the neurotrophins, nerve growth factor (NGF) and brain-derived growth factor (BDNF), and secondly, the GDNF family of ligands (GFLs). We provide an overview of the pain pathway, and the pain-producing effects of these different proteins. We summarize accumulating preclinical and clinical findings with a focus on musculoskeletal pain, and on osteoarthritis in particular, because the musculoskeletal system is the most prevalent source of chronic pain and of disability, and clinical testing of these novel agents - often biologics- is most advanced in this area.

中文翻译:

针对神经营养因子:解决肌肉骨骼疼痛的新方法。

慢性疼痛代表了全球尚未满足的医疗需求。近年来,对新一代新颖,安全,基于机制的止痛治疗的追求集中在神经营养因子上,神经营养因子是一大类分泌蛋白,它们控制着不同神经元群体的生长和存活,但出生后却参与其中。疼痛的发生和维持,在周围和中枢神经系统都有生物活性。在这篇叙述性综述中,我们讨论了神经营养蛋白在疼痛中作用的两个家族:首先是神经营养蛋白,神经生长因子(NGF)和脑源性生长因子(BDNF),其次是GDNF配体(GFL)家族。我们提供了疼痛途径的概述,以及这些不同蛋白质产生疼痛的作用。
更新日期:2020-04-18
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