Abstract Common scab of potato is an important disease caused by Streptomyces scabies. Biological control of this disease was previously demonstrated under controlled and field conditions using Pseudomonas synxantha LBUM223, a phenazine-1-carboxylic acid (PCA)-producer. To better understand the impact of PCA on the pathogen, RNA-seq analyses of S. scabies confronted with wild-type LBUM223, its isogenic PCA-deficient mutant and purified PCA were performed. Following exposure to wild-type LBUM223 or purified PCA (but not to the isogenic PCR-deficient mutant), 12%–14% of all S. scabies genes were differentially expressed, including key genes involved in pathogenicity/virulence, mycelium differentiation, and increased oxidative stress in S. scabies.

中文翻译：

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产生吩嗪-1-羧酸的合成假单胞菌 LBUM223 改变了马铃薯普通疮痂病的病原体链霉菌疥疮的转录组

摘要 马铃薯普通疮痂病是由链霉菌疥疮引起的重要病害。先前使用 Pseudomonas synxantha LBUM223（吩嗪-1-羧酸 (PCA) 生产者）在受控和田间条件下证明了对该病的生物控制。为了更好地了解 PCA 对病原体的影响，对与野生型 LBUM223、其同基因 PCA 缺陷型突变体和纯化 PCA 的 S.sc疮进行了 RNA-seq 分析。暴露于野生型 LBUM223 或纯化的 PCA（但不暴露于等基因 PCR 缺陷突变体）后，12%–14% 的疥疮基因发生差异表达，包括参与致病性/毒力、菌丝体分化和增加 S. scies 中的氧化应激。