The dissipation dynamic and residues of spiroxamine in open‐field‐grown strawberries were determined using liquid chromatography tandem mass spectrometry (LC–MS/MS). Spiroxamine application was performed according to Egyptian good agricultural practices recommendation. A QuEChERS‐based extraction method along with direct analysis with an LC–MS/MS analytical method were optimized and validated, and the specificity of the techniques used was considered satisfactory. Good linearity (R ² > 0.999) was obtained for spiroxamine within the range of 0.001–0.1 μg/ml. The mean recoveries varied between 97.1 and 108.2%, with inter‐ and intra‐day precision (RSD) <4.9%. The limit of quantitation for spiroxamine was 0.001 mg/kg. The results indicated that spiroxamine degradation in strawberry followed first–order kinetics (R ² > 0.9929) with an estimated half‐life value of 4.71 days. Considering the Australian maximum residue limit (0.05 mg/kg) in strawberry and based on the results from residue trials with a preharvest interval of 14 days for strawberry, compliance can be expected. The present results could provide guidance to fully evaluate the risks of spiroxamine residues, preventing any potential health risk to consumers.

中文翻译：

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液相色谱串联质谱法研究田间生长草莓中螺索明的残留，消散和风险评估。

使用液相色谱串联质谱法（LC-MS / MS）测定了田间生长草莓中spiroxamine的消散动态和残留。根据埃及良好农业规范的建议进行了氨氯吡胺的施用。基于QuEChERS的提取方法以及采用LC-MS / MS分析方法的直接分析得到了优化和验证，所用技术的特异性被认为是令人满意的。良好的线性度（R ²> 0.99-0.1）的spiroxamine在0.001-0.1μg/ ml的范围内。平均回收率在97.1至108.2％之间，日间和日内精度（RSD）<4.9％。spiroxamine的定量下限为0.001 mg / kg。结果表明，草莓中的spiroxamine降解遵循一级动力学（R ² > 0.9929），估计半衰期值为4.71天。考虑到澳大利亚草莓中的最大残留限量（0.05 mg / kg），并且基于草莓收获前间隔为14天的残留试验的结果，可以预期达到标准。本研究结果可为全面评估螺虫胺残留的风险提供指导，从而预防对消费者的任何潜在健康风险。