Abstract

A simple and efficient method for the synthesis of dihydro-8H-acenaphtho[1′,2′:4,5]pyrrolo[1,2-a]imidazole-diol derivatives via one-pot, four-component reaction of 1,1-bis(methylthio)-2-nitroethene, various amines, and acenaphthoquinone was developed. All the reactions were carried out in ethanol at reflux without any catalyst. The main advantages of this method are good to high yields, experimental simplicity, mild reaction conditions, simple workup, and easy purification.

Graphic abstract

中文翻译：

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二氢-8 H苊并[1',2':4,5]吡咯并[1,2-a]咪唑-二醇衍生物的一锅法合成

摘要

一种通过一锅四组分反应合成二氢-8 H-苊并[1',2':4,5]吡咯并[1,2 - a ]咪唑-二醇衍生物的简单有效方法，开发了 1-双（甲硫基）-2-硝基乙烯、各种胺和苊醌。所有反应均在无任何催化剂的情况下在乙醇中回流进行。该方法的主要优点是收率高，实验简单，反应条件温和，后处理简单，易于纯化。

图形摘要