Abstract

The development of multifunctional nanomaterials can greatly improve therapeutic efficacy in treating disease. In this present study, we report a new class of drug delivery system to maximize the therapeutic potential in treating cardiovascular disease. Synaptic acid encapsulated selenium-mesoporous silica (SA-PSiO₂-SeNDs-PEG) nanocomposite was synthesized via the conjugation of synaptic acid (SA) with encapsulated selenium-mesoporous silica. This nanocomposite showed a more stable and sustainable SA release capacity in the delivery system. Furthermore, the treatment of SA-PSiO₂-SeNDs-PEG nanocomposite reduced the reactive oxygen species (ROS) stress via the 2′, 7′-dichlorofluorescein diacetate (DCFH-DA) fluorescence intensity measurements in vitro. Furthermore, serum content analysis revealed a drop in the low-density lipoprotein level. The histological analysis resulted in no morphological difference in the mice tissue section treated with SA-PSiO₂-SeNDs-PEG nanocomposite as compared to the mice treated with saline solution, signifying no side effects occurred using this drug delivery platform. In short, SA-PSiO2-SeNDs-PEG nanocomposite are novel drug delivery platforms that will be potentiating the treatment of cardiovascular disease with more insights that are elucidated.

中文翻译：

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硒介孔二氧化硅纳米复合材料包裹的突触酸：一种治疗心血管疾病的潜在药物

摘要

多功能纳米材料的开发可以大大提高治疗疾病的疗效。在本研究中，我们报告了一种新型的药物递送系统，可最大程度地发挥治疗心血管疾病的潜力。突触酸包埋的硒介孔二氧化硅（SA-PSiO ₂ -SeNDs-PEG）纳米复合材料是通过突触酸（SA）与包囊的硒介孔二氧化硅的缀合而合成的。该纳米复合材料在递送系统中显示出更稳定和可持续的SA释放能力。此外，SA-PSiO _2的处理-SeNDs-PEG纳米复合材料通过体外2'，7'-二氯荧光素二乙酸酯（DCFH-DA）荧光强度测量降低了活性氧（ROS）应力。此外，血清含量分析显示低密度脂蛋白水平下降。组织学分析与用盐溶液处理的小鼠相比，在用SA-PSiO ₂ -SeNDs-PEG纳米复合物处理的小鼠组织切片中没有形态学差异，表明使用该药物递送平台没有发生副作用。简而言之，SA-PSiO2-SeNDs-PEG纳米复合材料是新型的药物输送平台，将通过更多的见解来加强心血管疾病的治疗。