Abstract

As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport of intracellular cargo and the formation of endosomal tubules. Ras-related protein (Rab) coordinates many steps of membrane transport and are involved in the regulation of KIF16B-mediated vesicle trafficking. Data obtained from clinical research suggest that KIF16B has a potential effect on the disease processes in intellectual disability, abnormal lipid metabolism, and tumor brain metastasis. In this review, we summarize recent advances in the structural and physiological characteristics of KIF16B as well as diseases associated with KIF16B disorders, and speculating its role as a potential adaptor for intracellular cholesterol trafficking.

Graphic Abstract

中文翻译：

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PX域驱动蛋白KIF16B和微管依赖的细胞内运动。

摘要

作为kinesin-3家族的成员，kinesin家族成员16B（KIF16B）具有特征性的PhoX同源性（PX）结构域，该结构域与包含磷脂酰肌醇3-磷酸酯（PI（3）P）的膜结合并沿着微管细丝移动到通过在各种细胞类型的茎区域中的线圈盘绕的线圈调节的过程来实现正向结束。KIF16B的生理功能支持细胞内货物的运输和内体小管的形成。Ras相关蛋白（Rab）协调膜运输的许多步骤，并参与KIF16B介导的囊泡运输的调节。从临床研究中获得的数据表明，KIF16B在智力残疾，异常脂质代谢和肿瘤脑转移方面对疾病过程具有潜在影响。在这篇评论中

图形摘要