当前位置: X-MOL 学术Macromol. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Outstanding Degradation Resistance of Hyaluronic Acid Achieved by Flavonoid Conjugations: Rheological Behavior
Macromolecular Research ( IF 2.4 ) Pub Date : 2019-12-10 , DOI: 10.1007/s13233-020-8068-2
Kantappa Halake , Jonghwi Lee

The functional conjugations with natural polyphenols could be a working strategy for accomplishing the degradation resistance of hyaluronic acids (HA). Herein, a series of HA conjugates with four different polyphenols with wide ranges in the degree of substitution were systematically prepared. The degradation rate could be retarded in a wide range without crosslinking: The conjugates having polyphenolic aglycone (catechin or quercetin) maintained their structures, as identified by viscosity, for up to 7 weeks in the presence of hyaluronidase. This retardation was outstanding compared to those reported from previous studies, and the physical mixtures of HA and polyphenols still showed significantly more retarded degradation than pristine HA. The degradation resistance could be controlled by varying the feed ratio of polyphenols. This conjugation method of polyphenols could open up new application areas of HA with the outstanding degradation resistance.


中文翻译:

类黄酮缀合获得的杰出的透明质酸降解抗性:流变行为

与天然多酚的功能结合可能是实现透明质酸(HA)的抗降解性的工作策略。在本文中,系统地制备了具有四种不同的多酚,其取代度范围广的一系列HA偶联物。无需交联,降解速率可在很宽的范围内得到抑制:在透明质酸酶的存在下,具有多酚苷元(儿茶素或槲皮素)的缀合物可以保持其结构(由粘度确定)长达7周。与以前的研究相比,这种阻滞作用非常出色,而且HA和多酚的物理混合物仍然比原始HA表现出明显更高的阻滞降解作用。耐降解性可以通过改变多酚的进料比来控制。
更新日期:2019-12-10
down
wechat
bug