Lipid membranes and their applications in analytical biochip devices represent a great tool for the study of membrane dynamics and the related biological phenomena. Lipid-membrane-assisted surface-sensitive sensors have employed to provide biological information as they improve molecular survivability as well as rule out incorrect signals arising from unwanted nonspecific binding between target molecules with sensor surfaces. To enhance the accuracy of the signal as well as the sensitivity of biochip sensors, a variety of strategies have been employed. Here, we introduce various types of in vitro model membrane platforms/techniques and discuss current challenges in the lipid-membrane-assisted surface-sensitive analytical sensors application.

中文翻译：

---

使用模型膜的表面敏感性分析装置及对生物传感器芯片的挑战

脂质膜及其在分析生物芯片设备中的应用是研究膜动力学和相关生物学现象的重要工具。脂质膜辅助的表面敏感传感器已被用来提供生物学信息，因为它们提高了分子的生存能力，并排除了目标分子与传感器表面之间不必要的非特异性结合所引起的错误信号。为了提高信号的准确性以及生物芯片传感器的灵敏度，已采用了多种策略。在这里，我们介绍了各种类型的体外模型膜平台/技术，并讨论了脂质膜辅助表面敏感分析传感器应用中的当前挑战。