Development of the novel delivery provides optimal drug delivery via facilitated transcorneal penetration and ultimately improved retention time in eye. The present study was to fabricate and evaluate the performance of ocular inserts of Olopatadine hydrochloride by consuming polymers such as hydroxypropyl methylcellulose, gelatin, and chitosan at various concentrations with different plasticizers using solvent casting technique. Prepared formulations were evaluated for thickness, weight variations, drug content, surface pH, swelling studies, and in vitro drug release. Fourier transform infrared spectroscopy studies showed that interaction occurred between polymer and drug, and successful drug entrapment occurred in the matrix. All formulations showed excellent film-forming capacity with good thickness and weight uniformity. Folding endurance proved that the inserts were soft, elastic, and flexible. Chitosan-based ocular inserts showed greater swelling index as compared to gelatin and hydroxypropyl methylcellulose inserts. In vitro studies showed prolonged drug release and followed zero-order kinetic model and non-Fickian drug release.

中文翻译：

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盐酸奥洛他定眼部植入物的制备与评价

新型递送的开发通过促进经角膜渗透并最终改善在眼中的保留时间来提供最佳的药物递送。本研究是通过使用溶剂浇铸技术以不同的增塑剂消耗不同浓度的羟丙基甲基纤维素、明胶和壳聚糖等聚合物来制造和评估盐酸奥洛他定眼部插入物的性能。对制备的制剂的厚度、重量变化、药物含量、表面 pH 值、溶胀研究和体外药物释放进行评估。傅里叶变换红外光谱研究表明，聚合物和药物之间发生了相互作用，药物成功包埋在基质中。所有配方都显示出优异的成膜能力，具有良好的厚度和重量均匀性。耐折叠性证明了插入物柔软、有弹性和柔韧。与明胶和羟丙基甲基纤维素插入物相比，基于壳聚糖的眼部插入物显示出更大的膨胀指数。体外研究显示药物释放延长，遵循零级动力学模型和非 Fickian 药物释放。