The objective of this work was to develop a potential selective radiotracer for the non-invasive assessment of heart imaging. [125I]iododobutamine was obtained via direct electrophilic substitution reaction with a high labeling yield of 96.79 ± 0.86%. The in vivo biodistribution of iodinated dobutamine showed high heart uptake of 31.49 ± 1.3%ID/g at 2 min after injection with low lungs and liver consumption which alleviate rapid myocardial imaging with significant minimum radiation hazards risk to the patients. Receptor blocking study showed reduction of heart uptake to 0.9 ± 0.01% which confirm the selectivity and specificity of [125I]iododobutamine for beta-adrenoceptors.

中文翻译：

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[125I]碘多巴酚丁胺作为心肌灌注成像放射性示踪剂的放射合成、色谱评价和生物分布

这项工作的目的是开发一种潜在的选择性放射性示踪剂，用于心脏成像的非侵入性评估。[125I]碘多巴酚丁胺通过直接亲电取代反应获得，标记产率为96.79±0.86%。碘化多巴酚丁胺的体内生物分布显示，注射后 2 分钟的心脏摄取量高达 31.49 ± 1.3% ID/g，肺和肝脏消耗量低，可缓解快速心肌成像，同时对患者的辐射危害风险显着降低。受体阻断研究显示心脏摄取降低至 0.9 ± 0.01%，这证实了 [125I] 碘多巴酚丁胺对 β-肾上腺素能受体的选择性和特异性。