Osteosarcoma is the most common primary malignant tumor of bone, particularly among children and adolescents. Advances in imaging, surgical techniques, and implants have dramatically reduced the need for amputation in the past three decades. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) shows impressive advantages of deeper tissue penetration and higher spatial resolution, which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma. To the best of our knowledge, this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.

骨肉瘤是最常见的原发性骨恶性肿瘤，尤其是在儿童和青少年中。在过去的三十年中，成像技术，外科技术和植入物的进步极大地减少了截肢的需求。最近，在第二个近红外窗口（NIR-II，1,000–1,700 nm）中进行的体内荧光成像显示出更深的组织穿透力和更高的空间分辨率的显着优势，这使其成为早期诊断和术后观察的有希望的工具骨肉瘤。据我们所知，本文是首次开发与骨肉瘤靶向寡肽偶联的新型NIR-II荧光探针，用于异种移植原位骨肉瘤小鼠模型中的分子肿瘤成像。