Introduction and objectives

Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary.

Materials and methods

A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. TFVL loops were classified into one of three categories depending of their geometric shape (symmetric, convex, and concave). Respiratory rate (Rr), presence of API+, and the number of exacerbations during the following year were also recorded.

Results

Children with concave loops had more exacerbations in the following year (OR = 6.8 [IC95% 3.33;13.91]). Infants API + were also significantly more related to concave loops (OR = 10.02 [IC 95% 4.53; 22.15]). Rr was higher in infants with concave loops (44+/−15.5 vs. 36.6 +/−12.6; p < 0.01).

Conclusion

Infants with a concave TFVL have a higher probability of experiencing exacerbations in the following year, and are at a higher risk of suffering asthma.

中文翻译：

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使用潮气流量环形状预测喘息婴儿的呼吸系统疾病结局。

介绍和目标

通过强制呼气技术测量，哮喘预测指数（API +）为正的喘息（RW）婴儿的肺功能较低。婴儿潮气量环（TFVL）易于实施，无需镇静。

材料和方法

成功测量了216名喘息婴儿，其中183名被随访了一年多。TFVL环根据其几何形状（对称，凸形和凹形）分为三类之一。还记录了下一年的呼吸频率（Rr），API +的存在和加重次数。

结果

第二年，有凹环的儿童病情加重（OR = 6.8 [IC95％3.33; 13.91]）。婴儿API +与凹环的相关性也更高（OR = 10.02 [IC 95％4.53; 22.15]）。凹形concave婴儿的Rr较高（44 +/- 15.5 vs. 36.6 +/- 12.6； p <0.01）。

结论

TFVL凹陷的婴儿在来年加重的可能性更高，患哮喘的风险也更高。