We investigated the effect of a chronic palatable diet rich in simple sugars on memory of different degrees of emotionality in male adult rats, and on hippocampal plasticity markers in different stages of development. On postnatal day (PND) 21, forty-five male Wistar rats were divided in 2 groups, according to their diet: (1-Control) receiving standard lab chow or (2-Palatable Diet) receiving both standard chow plus palatable diet ad libitum. At PND 60, behavioral tests were performed to investigate memory in distinct tasks. Hippocampal plasticity markers were investigated at PND 28 in half of the animals, and after the behavioral tests. Palatable diet consumption induced an impairment in memory, aversive or not, and increased Na+ , K+ -ATPase activity, both at PND 28, and in the adulthood. Synaptophysin, brain-derived neurotrophic factor (BDNF), and protein kinase B (AKT) and phosphorylated AKT were reduced in the hippocampus at PND 28. However, at PND 75, this diet consumption led to increased hippocampal levels of synaptophysin, spinophilin/neurabin-II, and decreased BDNF and neuronal nitric oxide synthase. These results showed a strongly association of simple sugars-rich diet consumption during the development with memory impairments. Plasticity markers are changed, with results that depend on the stage of development evaluated.

中文翻译：

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在发育过程中食用富含单糖的美味饮食会损害不同程度情绪的记忆，并根据大鼠的年龄改变海马的可塑性

我们研究了富含单糖的长期美味饮食对雄性成年大鼠不同程度情绪记忆的影响，以及对不同发育阶段海马可塑性标记的影响。在出生后第 21 天 (PND)，45 只雄性 Wistar 大鼠根据饮食分为 2 组：(1-对照)接受标准实验室食物或(2-适口饮食)接受标准食物加适口饮食。在 PND 60 时，进行行为测试来调查不同任务中的记忆。在 PND 28 时以及行为测试后，对一半动物的海马可塑性标记进行了研究。在 PND 28 和成年期，可口的饮食消耗会导致记忆力受损（无论是否厌恶），并增加 Na+、K+ -ATP 酶活性。PND 28 时，海马中的突触素、脑源性神经营养因子 (BDNF)、蛋白激酶 B (AKT) 和磷酸化 AKT 减少。然而，在 PND 75 时，这种饮食导致海马突触素、亲脊髓蛋白/神经蛋白水平增加-II，并减少 BDNF 和神经元一氧化氮合酶。这些结果表明，发育过程中富含单糖的饮食摄入与记忆障碍密切相关。可塑性标记发生变化，结果取决于评估的发育阶段。