The maturation and development of T cells were not completed until T cells were selected in thymus. It was not until the early 1960s that j.f.a.p. discovered the importance of thymus in T cell development. Twelve healthy piglets were randomly divided into two groups, the experimental group (LGG group) and the control group (saline group). The LGG group piglets were given 1 ml LGG (6 × 109 CFU/ml) per day. The saline group was given 1 ml of normal saline per day. The piglets were slaughtered at 30 days and 45 days, respectively, and the MLN, jejunum and ileum PPs, LP of the piglets were taken. The expression of CD3+CD4+ T lymphocytes was detected by flow cytometry, and intestinal villi development was observed by intestinal paraffin section. The results showed that the flow cytometry results at 30 days and 45 days showed that the CD3+CD4+ T lymphocytes in the MLN group were significantly different from those in the saline group (P < 0.05, P < 0.01).The CD3+CD4+ T lymphocytes in the jejunum PP of piglets in LGG group were significantly different from those in saline group (P < 0.05). The CD3+CD4+ T lymphocytes in the ileum PP of the LGG group were significantly different from those in the saline group (P < 0.05, P < 0.01). CD3+CD4+ T lymphocytes and normal saline in the piglets of the LGG group There was a significant difference between the two groups (P < 0.001, P < 0.05). P < 0.001). HE staining results showed the length of the LGG group ileal villi in piglets at 30 days, 45 days was significantly different from that in normal saline group (P < 0.01, P < 0.01). LGG can also regulate the proliferation of T lymphocytes in the intestine of early weaned piglets at 30 days and 45 days increase the number of CD3+CD4+ T lymphocytes.

中文翻译：

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鼠李糖乳杆菌GG对不同时期仔猪T淋巴细胞和肠绒毛发育的调节作用。

直到在胸腺中选择了T细胞，T细胞的成熟和发育才完成。直到1960年代初，jfap才发现胸腺在T细胞发育中的重要性。将12只健康仔猪随机分为两组，实验组（LGG组）和对照组（盐水组）。LGG组仔猪每天给予1 ml LGG（6×109 CFU / ml）。每天给生理盐水组1毫升生理盐水。分别在30天和45天屠宰仔猪，并取仔猪的MLN，空肠和回肠PP，LP。流式细胞术检测CD3 + CD4 + T淋巴细胞的表达，并用肠石蜡切片观察肠绒毛的发育。结果显示，在30天和45天的流式细胞仪检测结果表明，MLN组的CD3 + CD4 + T淋巴细胞与生理盐水组的CD3 + CD4 + T淋巴细胞有显着差异（P <0.05，P <0.01）。 LGG组仔猪空肠PP中的淋巴细胞与生理盐水组比较差异有统计学意义（P <0.05）。LGG组回肠PP中的CD3 + CD4 + T淋巴细胞与生理盐水组的CD3 + CD4 + T淋巴细胞显着不同（P <0.05，P <0.01）。LGG组仔猪的CD3 + CD4 + T淋巴细胞和生理盐水两组之间存在显着差异（P <0.001，P <0.05）。P <0.001）。HE染色结果显示，LGG组仔猪回肠绒毛长度在30、45天与生理盐水组明显不同（P <0.01，P < 0.01）。LGG还可以在30天和45天增加断奶仔猪肠道中T淋巴细胞的增殖，从而增加CD3 + CD4 + T淋巴细胞的数量。