Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.

中文翻译：

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ILC3s：进餐时保持肠道完整性的节奏保持者。

在白天，必须周期性地增加肠道上皮屏障的通透性（允许营养吸收），以增强对潜在有害成分的保护。Seillet等。证明摄取食物后，肠神经元来源的VIP通过诱导ILC3产生保护性IL-22来促进预期的粘膜免疫。