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2 H SOLCOR: A Novel Tool for Reducing Volume Variation as A Source of Error in External Standard Quantitative NMR
Magnetic Resonance in Chemistry ( IF 2 ) Pub Date : 2020-06-10 , DOI: 10.1002/mrc.5027
Jason Ewanicki 1 , William Kim 2 , Wei Wang 1
Affiliation  

Tube to tube volume difference presents a challenge in obtaining correct external standard quantitative NMR (esqNMR) results. Deuterium (2H) NMR is easily observable, intrinsically quantitative, present in all samples, free of interfering signals, and insensitive to probe tune/match and sample saltiness. These properties make 2H peak integral an ideal parameter in esqNMR for correcting volume differences between the reference standard and analyte. We demonstrate a novel and practical technique abbreviated as “2H SOLCOR” (2H SOLvent CORrected), where the 2H peak integral from the solvent is used as a universal internal standard to correct volume variations in NMR tubes, thereby improving accuracy and precision of esqNMR method. Herein, this simple yet effective technique is described, and practical considerations for successful implementation are presented. 2H SOLCOR can be applied anywhere esqNMR is used, including where precious samples need to be accurately quantified for qualification as an authentic analytical standard.

中文翻译:

2 H SOLCOR:一种用于减少作为外标定量 NMR 误差来源的体积变化的新工具

管与管的体积差异对获得正确的外标定量 NMR (esqNMR) 结果提出了挑战。氘 (2H) NMR 易于观察,本质上是定量的,存在于所有样品中,没有干扰信号,并且对探针调谐/匹配和样品咸度不敏感。这些特性使 2H 峰积分成为 esqNMR 中用于校正参考标准和分析物之间的体积差异的理想参数。我们展示了一种缩写为“2H SOLCOR”(2H SOLvent CORrected)的新颖实用技术,其中溶剂的 2H 峰积分用作通用内标来校正 NMR 管中的体积变化,从而提高 esqNMR 方法的准确度和精密度. 在这里,描述了这种简单而有效的技术,并提出了成功实施的实际考虑因素。2H SOLCOR 可应用于使用 esqNMR 的任何地方,包括需要准确量化珍贵样品以鉴定为可靠分析标准的地方。
更新日期:2020-06-10
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