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Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?
Nature Reviews Microbiology ( IF 88.1 ) Pub Date : 2020-05-01 , DOI: 10.1038/s41579-020-0353-8
Jennifer L Small-Saunders 1 , Laura M Hagenah 2 , David A Fidock 1, 2
Affiliation  

Resistance to the current first-line antimalarials threatens the control of malaria caused by the protozoan parasite Plasmodium falciparum and underscores the urgent need for new drugs with novel modes of action. Here, we present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria. Resistance to the current first-line antimalarials threatens the control of malaria caused by Plasmodium falciparum and underscores the urgent need for new drugs with novel modes of action. Small-Saunders, Hagenah and Fidock present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria.

中文翻译:

扭转局面:针对 PfCRT 对抗耐药性恶性疟?

对目前一线抗疟药的耐药性威胁到由原生动物寄生虫恶性疟原虫引起的疟疾的控制,并强调迫切需要具有新作用模式的新药。在这里,我们提出这样的论点,即寄生虫的氯喹抗性转运蛋白 (PfCRT) 构成了对抗耐多药疟疾的有希望的目标。对目前一线抗疟药的耐药性威胁到对恶性疟原虫引起的疟疾的控制,并强调迫切需要具有新作用方式的新药。Small-Saunders、Hagenah 和 Fidock 提出了这样的论点,即寄生虫的氯喹抗性转运蛋白 (PfCRT) 构成了对抗耐多药疟疾的有希望的目标。
更新日期:2020-04-24
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