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Interleukin-31 interaction with inflammasome: A promising diagnostic and prognostic panel for early sepsis identification in critically ill patients
Cytokine ( IF 3.8 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.cyto.2020.155102
Mona Mohamed Watany 1 , Maram Ibrahim Elmazny 2 , Elham Mohamed Nasif 3
Affiliation  

PURPOSE This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1ß and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. METHODS Serum levels of IL-31, IL-1ß and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 with SIRS, 30 with septic shock and 30 healthy controls. RESULTS Lower levels of IL-31 were found in sepsis (10.21 ± 4.34 pg/ml) compared to SIRS (16.74 ± 3.18 pg/ml) and to controls with the lowest levels detected in septic shock (6.26 ± 2.72 pg/ml). IL-1ß and NLRP3 levels were higher in sepsis (54.99 ± 14.11 pg/ml and 9.93 ± 2.38 ng/ml) compared to SIRS (27.8 ± 6.94 pg/ml and 4.86 ± 1.33 ng/ml) with the highest levels seen in septic shock (125.1 ± 32.79 pg/ml and 19.43 ± 6.48 ng/ml) respectively. IL-31 discriminated sepsis in patients showing SIRS with 80% sensitivity and 70% specificity and, identified septic shock with 78.6% sensitivity and 60.3% specificity. IL-1ß identified sepsis from SIRS with 93.3% and 83.3% specificity. NLRP3 discriminated sepsis from SIRS with 94.5% sensitivity and 93.3% specificity. And, with sensitivity 99.1% and 90.1% and specificity 98.9% and 80% IL-1ß and NLRP3 could respectively define septic shock. A panel of combined markers provided 100% sensitivity and specificity. The three biomarkers proved to be independent prognostic biomarkers. At 95% CI, IL-31 hazard ratio (HR) was 0.716, p = 0.001; IL-1β HR was 1.023, p ≤ 0.001; and NLRP3 HR was 1.114, p ≤ 0.001. Additionally, IL-1ß proved to be an independent predictor of septic shock (β = 0.355; p = 0.035). CONCLUSION The cross-relation between IL and 31, IL-1ß and NLRP3 in sepsis can provide a promising diagnostic and prognostic panel.

中文翻译:

白细胞介素 31 与炎症小体的相互作用:用于危重患者早期脓毒症识别的有前景的诊断和预后面板

目的 本病例对照研究旨在评估使用一组 IL-31、IL-1ß 和 NLRP3 区分脓毒症与全身炎症反应综合征 (SIRS) 并预测脓毒性休克的能力。方法 149 名参与者的 IL-31、IL-1ß 和 NLRP3 血清水平通过 ELISA 测量;38 例败血症,51 例 SIRS,30 例感染性休克和 30 例健康对照。结果 与 SIRS (16.74 ± 3.18 pg/ml) 和感染性休克中检测到的最低水平 (6.26 ± 2.72 pg/ml) 的对照相比,脓毒症患者的 IL-31 水平较低 (10.21 ± 4.34 pg/ml)。与 SIRS(27.8 ± 6.94 pg/ml 和 4.86 ± 1.33 ng/ml)相比,脓毒症患者的 IL-1ß 和 NLRP3 水平更高(54.99 ± 14.11 pg/ml 和 9.93 ± 2.38 ng/ml),脓毒症患者的水平最高冲击(125.1 ± 32.79 pg/ml 和 19.43 ± 6.48 ng/ml)。IL-31 以 80% 的敏感性和 70% 的特异性区分显示 SIRS 的患者中的败血症,并以 78.6% 的敏感性和 60.3% 的特异性识别感染性休克。IL-1ß 以 93.3% 和 83.3% 的特异性识别来自 SIRS 的败血症。NLRP3 以 94.5% 的敏感性和 93.3% 的特异性区分脓毒症和 SIRS。并且,IL-1ß 和 NLRP3 的敏感性为 99.1% 和 90.1%,特异性为 98.9% 和 80%,可以分别定义感染性休克。一组组合标记提供了 100% 的灵敏度和特异性。这三种生物标志物被证明是独立的预后生物标志物。在 95% CI 下,IL-31 风险比 (HR) 为 0.716,p = 0.001;IL-1β HR 为 1.023,p ≤ 0.001;NLRP3 HR 为 1.114,p ≤ 0.001。此外,IL-1ß 被证明是感染性休克的独立预测因子(β = 0.355;p = 0.035)。结论 IL 和 31 之间的交叉关系,
更新日期:2020-07-01
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