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Mechanisms and consequences of subcellular RNA localization across diverse cell types.
Traffic ( IF 4.5 ) Pub Date : 2020-04-29 , DOI: 10.1111/tra.12730
Krysta L Engel 1 , Ankita Arora 1 , Raeann Goering 1 , Hei-Yong G Lo 1 , J Matthew Taliaferro 1, 2
Affiliation  

Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing transcripts for localized translation. These transcripts play a functional role in maintaining cell physiology by enabling a quick response to changes in the cellular environment. Here, we review how RNA molecules are trafficked within cells, with a focus on the subcellular locations to which they are trafficked, mechanisms that regulate their transport and clinical disorders associated with misregulation of the process.

中文翻译:

跨多种细胞类型的亚细胞RNA定位的机制和后果。

本质上,所有单元都包含各种空间受限区域,这些区域对于执行特定功能非常重要。通常,这些区域包含专门的转录组,通过提供本地化翻译的转录本来促进这些功能。这些转录本通过对细胞环境的变化做出快速反应,在维持细胞生理中发挥功能性作用。在这里,我们回顾了RNA分子如何在细胞内被贩运,重点是被贩运到的亚细胞位置,调节其转运的机制以及与该过程失调相关的临床疾病。
更新日期:2020-04-15
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