The potential role of borophene as a radiosensitizer in PT and BNCT was investigated. Our study focused on two aspects: (1) the synthesis and characterization of borophene nanomaterials; and (2) biocompatibility and dose enhancement. To overcome the limitation of vapor-based technology, we successfully deployed the liquid-phase exfoliation (LPE) method to produce borophene targeting for biomedical applications. Bringing together spatial distribution and dose deposition, the in vitro microdosimetry study was carried out in the presence of borophene. A quantitative study of the dose enhancement ratio (DER) was performed with Monte-Carlo simulation. The synthesized borophene showed good biocompatibility with less than 10% cell death at a concentration of up to 0.2 mg ml-1. The uptake of borophene within individual cells penetrated through cell membranes but outside the nucleus. For proton PT, no significant change in the DER is found. For carbon PT, the DER increases by about 5% as the concentration of 10B reaches 1 mg g-1. For BNCT, a DER of more than 2 can be obtained for a concentration as low as 100 μg g-1. This study lays a foundation for utilizing novel borophene-based nanomaterials as radiosensitizers as well as imaging probes in cancer treatment.

中文翻译：

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在硼中子俘获疗法（BNCT）和粒子疗法（PT）中，硼烷作为放射增敏剂的潜在作用。

研究了硼苯在PT和BNCT中作为放射增敏剂的潜在作用。我们的研究集中在两个方面：（1）硼烷纳米材料的合成与表征；（2）生物相容性和剂量增加。为克服基于蒸汽的技术的局限性，我们成功地部署了液相剥落（LPE）方法来生产针对生物医学应用的靶向硼苯。将空间分布和剂量沉积结合在一起，在存在硼烷的情况下进行了体外微剂量测定研究。用蒙特卡洛模拟进行剂量增强比（DER）的定量研究。合成的硼苯在高达0.2 mg ml-1的浓度下表现出良好的生物相容性，细胞死亡少于10％。单个细胞内硼烷的吸收穿过细胞膜，但进入细胞核之外。对于质子PT，未发现DER的显着变化。对于碳PT，当10B的浓度达到1 mg g-1时，DER增加约5％。对于BNCT，对于低至100μgg-1的浓度，可以获得大于2的DER。该研究为在癌症治疗中利用新颖的基于硼烯的纳米材料作为放射增敏剂以及成像探针奠定了基础。