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In situ synthesis of polyamidoamine/β-cyclodextrin/silver nanocomposites on polyester fabric tailoring drug delivery and antimicrobial properties
Reactive & Functional Polymers ( IF 5.1 ) Pub Date : 2020-04-15 , DOI: 10.1016/j.reactfunctpolym.2020.104602
Amir Hossein Keshavarz , Majid Montazer , Neda Soleimani

Here, the polyester fabric was modified using polyamidoamine/β-cyclodextrin (β-CD)/silver nanocomposites to make a fabric with antibacterial and drug delivery properties. The aminolysis of polyester fabric with polyamidoamine led to the possible stable linkages with (β-CD)/Ag composites. The drug absorption and release behavior of the fabrics investigated in the water and phosphate buffer solutions confirming the maximum drug absorption of 16.9% after 24 h in which 45% of the loaded drug was slowly released in the buffer solution after 3 h. The synthesized nanocomposites on the fabric were detected by FESEM images and EDX mapping showed various percentages and distribution of the used elements. Also, FTIR analysis displayed some changes in the chemical structure of the functional groups. The XRD pattern of β-CD/Ag nanocomposite suggested a peak at 2θ = 44.6° with the calculated crystal size of 9.5 nm. The tensile strength unremarkably decreased according to the mechanical testing. Further, the treated fabrics indicated 100, 100 and 99% microbial reduction against E. coli, S. aureus and C. albican. Moreover, the cytotoxicity of the fabric against fibroblast cell was studied through MTT test. Based on the obtained results, it can suggest that the new modified polyester fabric can be used in drug delivery system.



中文翻译:

聚酰胺织物上聚酰胺酰胺/β-环糊精/银纳米复合材料的原位合成调整药物的传递和抗菌性能

在此,使用聚酰胺酰胺/β-环糊精(β-CD)/银纳米复合材料对聚酯织物进行改性,以制成具有抗菌和药物传递特性的织物。聚酯纤维与聚酰胺酰胺的氨解导致与(β-CD)/ Ag复合材料的稳定连接。在水和磷酸盐缓冲溶液中研究的织物的药物吸收和释放行为证实了24小时后16.9%的最大药物吸收,其中45%的负载药物在3小时后缓慢释放到缓冲溶液中。用FESEM图像检测织物上合成的纳米复合材料,EDX测绘表明所用元素的百分比和分布各不相同。同样,FTIR分析显示了官能团化学结构的一些变化。β-CD/ Ag纳米复合材料的XRD图谱显示在2θ= 44.6°处有一个峰,计算出的晶体尺寸为9.5 nm。根据机械测试,抗拉强度没有明显降低。此外,经处理的织物显示出100%,100%和99%的微生物减少大肠杆菌,金黄色葡萄球菌白色念珠菌。此外,通过MTT试验研究了织物对成纤维细胞的细胞毒性。基于获得的结果,可以暗示该新型改性聚酯织物可用于药物递送系统。

更新日期:2020-04-15
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