Background Infection with human papillomaviruses (HPVs) can cause benign and malignant tumours in the anogenital tract and the oropharynx both in men and women. The aim of the presented study was to investigate cervical, anal, and oral HPV-detection rates among women referred to colposcopy for abnormal Cervical Cancer (CaCx) screening results and assess the concordance of HPV-types among these anatomical sites. Methods Women referred to colposcopy at a single centre due to abnormal cytology, conducted for CaCx screening, were subjected to cervical Liquid-based Cytology (LBC) smear testing, anal and oral sampling. Routine colposcopy consisted in multiple biopsies and/or Endocervical Curettage (ECC). HPV-detection was performed by PCR genotyping in all three anatomical sites. In high-risk (hr) HPV-DNA positive samples either from anal canal or oral cavity, anal LBC cytology and anoscopy were performed, or oral cavity examination respectively. Descriptive statistics was used for the analysis of HPV-detection rates and phi-coefficient for the determination of HPV-positivity concordance between the anatomical sites. Results Out of 118 referred women, hr. HPV-DNA was detected in 65 (55.1%), 64 (54.2%) and 3 (2.5%) at cervix, anal canal and oral cavity respectively while low-risk HPV-DNA was detected in 14 (11.9%) and 11 (9.3%) at cervix and anal canal respectively. The phi-coefficient for cervix/anal canal was 0.392 for HPV16, 0.658 for HPV31, 0.758 for HPV33, − 0.12 for HPV45, 0.415 for HPV52 and 0.473 for HPV58. All values were statistically significant ( p < 0.001). Conclusions The results suggest that most HPV-types, high-risk and low-risk, detected in the cervix of women with prevalent cervical dysplasia, correlate with the ones detected in their anal canal. This particularly applies for the HPV-types included in the nonavalent HPV-vaccine (HPVs 6/11/16/18/31/33/45/52/58).

中文翻译：

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转诊接受阴道镜检查的女性的宫颈、肛门和口腔 HPV 检测以及 HPV 类型一致性

背景 人乳头瘤病毒（HPV）感染可导致男性和女性肛门生殖道和口咽部良性和恶性肿瘤。本研究的目的是调查因异常宫颈癌 (CaCx) 筛查结果而接受阴道镜检查的女性的宫颈、肛门和口腔 HPV 检出率，并评估这些解剖部位 HPV 类型的一致性。方法 因细胞学异常而转至单一中心进行阴道镜检查、进行 CaCx 筛查的女性，接受宫颈液基细胞学 (LBC) 涂片检测、肛门和口腔取样。常规阴道镜检查包括多次活检和/或宫颈管刮除术（ECC）。通过 PCR 基因分型在所有三个解剖部位进行 HPV 检测。对于来自肛管或口腔的高危（小时）HPV-DNA 阳性样本，分别进行肛门 LBC 细胞学检查和肛门镜检查，或口腔检查。使用描述性统计分析 HPV 检出率和 phi 系数，以确定解剖部位之间 HPV 阳性的一致性。结果 在 118 名被推荐的女性中，小时。子宫颈、肛管和口腔分别检出 65 例（55.1%）、64 例（54.2%）和 3 例（2.5%）HPV-DNA，14 例（11.9%）和 11 例（11 例）检出低危 HPV-DNA。 9.3%）分别位于子宫颈和肛管。子宫颈/肛管的 phi 系数对于 HPV16 为 0.392，对于 HPV31 为 0.658，对于 HPV33 为 0.758，对于 HPV45 为 0.12，对于 HPV52 为 0.415，对于 HPV58 为 0.473。所有值均具有统计显着性 (p < 0.001)。结论 结果表明，在患有普遍宫颈发育不良的女性的子宫颈中检测到的大多数 HPV 类型（高风险和低风险）与在肛管中检测到的 HPV 类型相关。这尤其适用于非价 HPV 疫苗中包含的 HPV 类型（HPV 6/11/16/18/31/33/45/52/58）。