Rotenone, a toxic rotenoid compound, has anti‐tumour effects on several cancers. This study aims to clarify the effect of rotenone on the proliferation, apoptosis, invasion and migration of colon cancer cells and tumourigenesis in nude mice. The present results show that rotenone significantly inhibited the proliferation, promoted the apoptosis, and suppressed the invasion and migration of colon cancer cells in a dose‐dependent manner. Rotenone inhibited PI3K/AKT pathway in LoVo and SW480 cells in a dose‐dependent manner. In addition, rotenone regulated the proliferation, apoptosis, invasion, migration and EMT of LoVo and SW480 cells through PI3K/AKT pathway. In colon cancer xenograft mice, rotenone inhibited tumour volume and weight in nude mice, inhibited PI3K/AKT pathway and EMT in vivo. Therefore, rotenone inhibited the proliferation, invasion and migration, promoted the apoptosis of colon cancer cells through PI3K/AKT pathway in vitro, and suppressed the tumourigenesis in nude mice in vivo.

中文翻译：

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鱼藤酮通过 PI3K/AKT 通路抑制结肠癌细胞的增殖、运动和上皮间质转化以及裸鼠的肿瘤发生。

鱼藤酮是一种有毒的类胡萝卜素化合物，对多种癌症具有抗肿瘤作用。本研究旨在阐明鱼藤酮对裸鼠结肠癌细胞增殖、凋亡、侵袭和迁移及肿瘤发生的影响。目前的结果表明，鱼藤酮以剂量依赖性方式显着抑制结肠癌细胞的增殖，促进细胞凋亡，并抑制结肠癌细胞的侵袭和迁移。鱼藤酮以剂量依赖性方式抑制 LoVo 和 SW480 细胞中的 PI3K/AKT 通路。此外，鱼藤酮通过PI3K/AKT通路调节LoVo和SW480细胞的增殖、凋亡、侵袭、迁移和EMT。在结肠癌异种移植小鼠中，鱼藤酮在裸鼠体内抑制肿瘤体积和重量，在体内抑制 PI3K/AKT 通路和 EMT。因此，鱼藤酮抑制了增殖，.