The synthesis and self‐assembly of peptide–polymer conjugates into fibrillar nanostructures are reported, based on the amyloidogenic peptide KLVFF. A strategy for rational synthesis of polymer–peptide conjugates is documented via tethering of the amyloidogenic peptide segment LVFF (Aβ_17‐20) and its modified derivative FFFF to the hydrophilic poly(ethylene glycol) monomethyl ether (mPEG) polymer via thio‐bromo based “click” chemistry. The resultant conjugates mPEG‐LVFF‐OMe and mPEG‐FFFF‐OMe are purified via preparative gel permeation chromatography technique (with a yield of 61% and 64%, respectively), and are successfully characterized via combination of spectroscopic and chromatographic methods, including electrospray ionization time‐of‐flight mass spectrometry. The peptide‐guided self‐assembling behavior of the as‐constructed amphiphilic supramolecular materials is further investigated via transmission electron microscopic and circular dichroism spectroscopic analysis, exhibiting fibrillar nanostructure formation in binary aqueous solution mixture.

中文翻译：

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硫-溴“点击”反应衍生的聚合物肽共轭物具有自组装的原纤维纳米结构。

据报道，基于淀粉样肽KLVFF，肽-聚合物共轭物的合成和自组装成纤维状纳米结构。一种用于聚合物-肽缀合物通过淀粉样蛋白形成肽区段LVFF的栓系进行了说明的合理的合成策略（Aβ _17-20）及其改性衍生物FFFF通过基于硫代溴的“点击”化学反应制成亲水性聚乙二醇单甲醚（mPEG）聚合物。所得的缀合物mPEG-LVFF-OMe和mPEG-FFFF-OMe通过制备型凝胶渗透色谱技术进行纯化（产率分别为61％和64％），并通过结合光谱和色谱方法（包括电喷雾）成功进行了表征电离飞行时间质谱 通过透射电子显微镜和圆二色性光谱分析进一步研究了所构造的两亲性超分子材料的肽引导的自组装行为，在二元水溶液混合物中显示出纤维状纳米结构的形成。